Document Detail

Progesterone-dependent immunomodulation.
MedLine Citation:
PMID:  16129958     Owner:  NLM     Status:  MEDLINE    
The biological effects of progesterone are mediated by a 34-kDa protein named the progesterone-induced blocking factor (PIBF). PIBF, synthesized by lymphocytes of healthy pregnant women in the presence of progesterone, inhibits arachidonic acid release as well as NK activity, and modifies the cytokine balance. Within the cell the full-length PIBF is associated with the centrosome, while secretion of shorter forms is induced by activation of the cell. PIBF induces nuclear translocation of STAT6 as well as PKC phosphorylation and exerts a negative effect on STAT4 phosphorylation. The concentration of PIBF in pregnancy urine is related to the positive or negative outcome of pregnancy; furthermore, premature pregnancy termination is predictable by lower than normal pregnancy PIBF values. In vivo data suggest the biological importance of the above findings. Treatment of pregnant Balb/c mice with the antiprogesterone RU 486 results in an increased resorption rate, which is associated with the inability of spleen cells to produce PIBF. High resorption rates induced by progesterone receptor block as well as those due to high NK activity are corrected by simultaneous PIBF treatment.
J Szekeres-Bartho; B Polgar; N Kozma; E Miko; G Par; L Szereday; A Barakonyi; T Palkovics; O Papp; P Varga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Chemical immunology and allergy     Volume:  89     ISSN:  1660-2242     ISO Abbreviation:  Chem Immunol Allergy     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-30     Completed Date:  2005-11-02     Revised Date:  2008-05-06    
Medline Journal Info:
Nlm Unique ID:  101183835     Medline TA:  Chem Immunol Allergy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  118-25     Citation Subset:  IM    
Department of Medical Microbiology and Immunology, Pecs University, Medical School, Pecs, Hungary.
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MeSH Terms
Abortifacient Agents, Steroidal / pharmacology
Cytokines / metabolism
Immunologic Factors / metabolism*
Killer Cells, Natural / immunology
Mifepristone / pharmacology
Pregnancy Outcome
Pregnancy Proteins / immunology,  urine
Progesterone / immunology*
Signal Transduction
Suppressor Factors, Immunologic / urine
Reg. No./Substance:
0/Abortifacient Agents, Steroidal; 0/Cytokines; 0/Immunologic Factors; 0/PIBF1 protein, human; 0/Pibf1 protein, mouse; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 57-83-0/Progesterone; 84371-65-3/Mifepristone

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