Document Detail

Progesterone deficiency and premature labour.
MedLine Citation:
PMID:  4812406     Owner:  NLM     Status:  MEDLINE    
Plasma oestradiol 17beta and progesterone levels in 11 patients admitted to hospital for threatened premature labour of unknown aetiology were compared with those of women at similar stages of gestation whose pregnancy was normal. Oestradiol levels in the study group were slightly higher than in the normal controls but their progesterone levels were significantly lower. This progesterone deficiency increased the oestradiol/progesterone ratio in the study group patients, and it increased still more as the progesterone withdrawal continued during premature labour.Since uterine activity during pregnancy is regulated by a balanced action of several factors a deficiency in progesterone, an opponent of uterine activity, creates a regulatory imbalance which, if uncorrected, provokes premature labour. An increase in uterine volume stimulates uterine activity, and the present study reinforced our previous conclusion that the uterine-volume/plasma-progesterone ratio is a more accurate measure of the state of regulatory balance than the progesterone level alone.The cause of the progesterone deficiency in these cases remains unexplained, but we suggest that placental growth and function are contributory factors. We are investigating ways of correcting the resulting imbalance in the regulatory mechanism.
A I Csapo; O Pohanka; H L Kaihola
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1974 Jan 
Date Detail:
Created Date:  1974-04-03     Completed Date:  1974-04-03     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  AIM; IM    
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MeSH Terms
Cervix Uteri / physiopathology
Estradiol / blood
Gestational Age
Obstetric Labor, Premature / blood,  etiology*
Organ Size
Placenta / growth & development,  physiopathology
Progesterone / blood*
Time Factors
Uterus / physiology
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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