Document Detail

Progesterone administration induces preimplantation embryonic loss in mice.
MedLine Citation:
PMID:  18692799     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of progesterone during early pregnancy on pregnancy maintenance in mice. DESIGN: Experimental study or laboratory investigation. SETTING: An established molecular reproduction laboratory, Department of Biotechnology, S.V. University. ANIMAL(S): Healthy virgin female Swiss albino mice of 8 weeks of age. INTERVENTION(S): After confirmation of the heat period, adult female mice were mated with mature healthy males to achieve pregnancy. Inseminated females received intraperitoneal injections of progesterone at doses of 0, 1, 3.5, 7, 15, 25, or 50 mg/kg body weight on the first, third, and seventh day of pregnancy. MAIN OUTCOME MEASURE(S): Preimplantation embryonic loss. RESULT(S): Pregnancy failure was evidenced by reduction in the number of embryos in females injected with 7 (25.12 %), 15 (38.44 %), 25 (100%), and 50 (100%) mg progesterone/kg body weight. In females with a successful pregnancy, the numbers of corpora lutea and postimplantation loss per dam were comparable across all groups. No increase in the incidence of malformed fetuses was found in any progesterone-treated groups. CONCLUSION(S): Administration of supranormal levels of progesterone during early pregnancy caused a reduction in the number of implantations and an increase in preimplantation loss in mice.
Challa Harini; Sri Bhashyam Sainath; Pamanji Sreenivasula Reddy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-09
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2137-41     Citation Subset:  IM    
Department of Biotechnology, Sri Venkateswara University, Tirupati, India.
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MeSH Terms
Blastocyst / drug effects,  pathology*
Dose-Response Relationship, Drug
Embryo Implantation
Embryo Loss / pathology
Progesterone / pharmacology*,  toxicity
Reg. No./Substance:

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