Document Detail

Progestagen-dependent effect on some plasma proteins during oral contraception.
MedLine Citation:
PMID:  2967233     Owner:  NLM     Status:  MEDLINE    
Seventeen healthy women received a combination of 0.030 mg of ethinyl estradiol and 0.150 mg of levonorgestrel or a combination of 0.030 mg of ethinyl estradiol and 0.150 mg of desogestrel for 2 years as oral contraception. Serum levels of sex hormone binding globulin, transcortin, ceruloplasmin, and pregnancy-associated protein were measured before contraception, during 3, 6, 12, 18, and 24 months of treatment, and 2 months after stopping the pill. Oral contraception with both preparations induced a similar, significant rise in both ceruloplasmin and pregnancy-associated protein. Sex hormone binding globulin levels rose significantly with the ethinyl estradiol-desogestrel, but not with the ethinyl estradiol-levonorgestrel combination. Transcortin increased with both preparations, more with the ethinyl estradiol-desogestrel combination.
P Liukko; R Erkkola; E W Bergink
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  25     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1988  
Date Detail:
Created Date:  1988-07-01     Completed Date:  1988-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  118-22     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Central Hospital of Turku, Finland.
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MeSH Terms
Blood Proteins / analysis*
Ceruloplasmin / blood
Contraceptives, Oral, Combined / pharmacology*
Ethinyl Estradiol / pharmacology*
Norgestrel / pharmacology
Norpregnenes / pharmacology
Pregnancy Proteins / blood
Progesterone Congeners / pharmacology*
Sex Hormone-Binding Globulin / blood
Transcortin / blood
Reg. No./Substance:
0/Blood Proteins; 0/Contraceptives, Oral, Combined; 0/Norpregnenes; 0/Pregnancy Proteins; 0/Progesterone Congeners; 0/Sex Hormone-Binding Globulin; 54024-22-5/Desogestrel; 57-63-6/Ethinyl Estradiol; 6533-00-2/Norgestrel; 797-63-7/Levonorgestrel; 9010-38-2/Transcortin; EC

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