Document Detail

Progenitor-derived endothelial cell response, platelet reactivity and haemocompatibility parameters indicate the potential of NaOH-treated polycaprolactone for vascular tissue engineering.
MedLine Citation:
PMID:  20687124     Owner:  NLM     Status:  In-Data-Review    
The haemocompatibility of NaOH-treated poly(ε-caprolactone) (PCL) has been evaluated in vitro by analysing several parameters, including plasma recalcification time, whole blood clotting time and platelet adhesion/activation. NaOH-treated PCL films showed a significant decrease in the clot formation speed and a reduced number of adhered platelets, which mainly exhibited non-activated morphologies. Furthermore, mature endothelial cells derived from peripheral endothelial progenitor cells were cultured on the polymer to investigate the effects of the endothelial lining on polymer haemocompatibility. Interestingly, cells cultured on NaOH-treated PCL films showed a significant stimulation of NO production. Although further research is required, NaOH treatment could be an interesting and simple strategy to modify PCL-based materials in order to enhance endothelial NO production, where compromised, and provide a better interaction of the scaffold with the blood components. In conclusion, these results reinforce the use of NaOH-treated PCL as a haemocompatible polymer for vascular tissue-engineering applications. Copyright © 2010 John Wiley & Sons, Ltd.
María-Concepción Serrano; Raffaella Pagani; Juan Peña; María Vallet-Regí; Juan-Valentín Comas; María-Teresa Portolés
Related Documents :
17795384 - Diamond coating of titanium alloys.
11689254 - A direct-staining method to evaluate the mucoadhesion of polymers from aqueous dispersion.
19783034 - Modulating cellular adhesion through nanotopography.
15119934 - Cell adhesion on artificial materials for tissue engineering.
25260714 - Sarcoplasmic/endoplasmic reticulum ca(2+) atpase c674 promotes ischemia- and hypoxia-in...
15195114 - Altered expression of adhesion molecules and epithelial-mesenchymal transition in silic...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of tissue engineering and regenerative medicine     Volume:  5     ISSN:  1932-7005     ISO Abbreviation:  J Tissue Eng Regen Med     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308490     Medline TA:  J Tissue Eng Regen Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  238-47     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Department of Biochemistry and Molecular Biology I, Faculty of Chemistry, Universidad Complutense, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A re-evaluation of the influence of maternal insulin-dependent diabetes on fetal nuchal translucency...
Next Document:  A new approach to heart valve tissue engineering: mimicking the heart ventricle with a ventricular a...