Document Detail


Progenitor cells for cardiac repair.
MedLine Citation:
PMID:  17321172     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Repair of diseased or injured myocardium by cell-based therapies is likely to require a multi-pronged approach. New myocytes will need to be generated, integrated with existing myocardial tissue, and perfused with a newly acquired vascular system. There are many potential avenues to achieve this goal, and optimizing repair is likely to require a synthetic therapeutic approach. In this review, we discuss several issues to be considered in cell-based cardiac repair, some progress which has been made toward this goal, and future directions.
Authors:
Sylvia M Evans; Christine Mummery; Pieter A Doevendans
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-12-21
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  18     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-06     Completed Date:  2007-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  153-60     Citation Subset:  IM    
Affiliation:
Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Medicine, University of California, San Diego, CA 92014, USA. syevans@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Cells / physiology
Heart / physiology*
Humans
Models, Biological
Myocardium / cytology
Myocytes, Cardiac / physiology
Neovascularization, Physiologic
Regeneration*
Stem Cell Transplantation*
Stem Cells / physiology*
Transplantation, Autologous / physiology
Transplantation, Homologous / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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