Document Detail

Profound refractory hypocalcemia after thyroidectomy in a patient receiving chronic oral bisphosphonate therapy.
MedLine Citation:
PMID:  16468539     Owner:  NLM     Status:  MEDLINE    
The use of oral bisphosphonates in the primary care setting is increasing, most commonly to preserve bone density and prevent the development or progression of osteoporosis. We report a case of profound hypocalcemia occurring in a patient who underwent thyroidectomy while receiving chronic oral risedronate therapy for osteoporosis. In addition, the hypocalcemia was refractory to treatment for several days, necessitating a prolonged hospital stay. A review of the literature yielded no similar cases to date. We propose that the frequently observed transient hypocalcemia after thyroidectomy was exacerbated by the alterations in calcium homeostasis produced by bisphosphonate therapy and urge cessation of these agents for several weeks prior to surgery. A review of the relevant literature is provided.
Bryan K Richmond
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  71     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2006-02-10     Completed Date:  2006-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  872-3     Citation Subset:  IM    
West Virginia University/Charleston Division, 3110 MacCorkle Ave. SE, Charleston, WV 25304, USA.
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MeSH Terms
Bone Density Conservation Agents / adverse effects*
Diphosphonates / adverse effects*
Etidronic Acid / adverse effects,  analogs & derivatives*
Goiter, Nodular
Hypocalcemia / etiology,  therapy*
Thyroidectomy / adverse effects*
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates; 105462-24-6/risedronic acid; 2809-21-4/Etidronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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