| Profound hypotension in a tetraplegic patient following angiotensin-converting enzyme inhibitor lisinopril. Case report. | |
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MedLine Citation:
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PMID: 7708426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present the case of a 60 year old C6 complete tetraplegic patient who developed profound hypotension following initiation of the angiotensin-converting enzyme inhibitor lisinopril to control blood pressure. Other causes of hypotension, such as myocardial infarction and sepsis was ruled out. Inhibition of the renin-angiotensin-aldosterone system was the probable cause of hypotension. This case demonstrates the critical importance of the renin-angiotensin-aldosterone axis in the maintenance of blood pressure in tetraplegic patients, who may lack input from the brain to sympathetic neurons, and therefore have increased reliance on the renin-angiotensin-aldosterone axis for the maintenance of blood pressure. Angiotensin-converting enzyme inhibitors should be avoided in tetraplegic patients, unless other treatment modalities are ineffective. |
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Authors:
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J K Schmitt; K S Koch; M Midha |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Paraplegia Volume: 32 ISSN: 0031-1758 ISO Abbreviation: Paraplegia Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-05-09 Completed Date: 1995-05-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985038R Medline TA: Paraplegia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 871-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, Virginia 23249. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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adverse effects* Blood Pressure / drug effects Humans Hypotension / chemically induced*, complications Lisinopril / adverse effects* Male Middle Aged Obesity / complications Quadriplegia / complications* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 83915-83-7/Lisinopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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