| Profound hypocalcemia following effective response to zoledronic acid treatment in a patient with juvenile Paget's disease. | |
| | |
MedLine Citation:
|
PMID: 20533067 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Juvenile Paget's disease (JPD) is a rare, autosomal recessive osteopathy. Although it has phenotypic overlap with Paget's disease of bone (PDB), it is probably a distinct entity. Because of its rarity, optimal disease management has not yet been established by randomized controlled trials. However, clinical, biochemical, and radiographic improvement has been reported after treatment with antiresorptive agents, including calcitonin and bisphosphonates (BPs). Compared with other BPs, zoledronic acid (ZOL) has a higher affinity to bone mineral and is a stronger inhibitor of the enzyme farnesyl pyrophosphate synthase (the main target of nitrogen-containing BPs), properties that explain the prolonged effect of ZOL on bone turnover and render it a therapeutic option for JPD, similar to PDB. We describe hereby, for the first time in the literature, the case of a patient with JPD who developed severe hypocalcemia and secondary hyperparathyroidism following effective treatment with ZOL. |
| | |
Authors:
|
Stergios A Polyzos; Athanasios D Anastasilakis; Ioannis Litsas; Zoe Efstathiadou; Marina Kita; Georgios Arsos; Efstratios Moralidis; Athanasios Papatheodorou; Evangelos Terpos |
Related Documents
:
|
18020547 - Treatment of adenosine deaminase deficiency. 11560797 - Osteopenia and osteoporosis in gastrointestinal diseases: diagnosis and treatment. 14584907 - Disease-specific expression of tartrate-resistant acid phosphatase isoforms. 9293817 - Fluorine-18-fdg pet in paget's disease of bone. 20447447 - Could a dysfunction of ferritin be a determinant factor in the aetiology of some neurod... 958617 - Myelographic evidence for nerve root enlargement in a case of charcot-marie-tooth disease. |
Publication Detail:
|
Type: Journal Article Date: 2010-06-09 |
Journal Detail:
|
Title: Journal of bone and mineral metabolism Volume: 28 ISSN: 1435-5604 ISO Abbreviation: J. Bone Miner. Metab. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9436705 Medline TA: J Bone Miner Metab Country: Japan |
Other Details:
|
Languages: eng Pagination: 706-12 Citation Subset: IM |
Affiliation:
|
Department of Endocrinology, Ippokration General Hospital, 13 Simou Lianidi, Thessaloniki, Greece. stergios@endo.gr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and relat...
Next Document: Risedronate improves proximal femur bone density and geometry in patients with osteoporosis or osteo...