| Profound alterations of the lipoprotein metabolism during danazol treatment in premenopausal women. | |
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MedLine Citation:
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PMID: 6724013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twelve women with pelvic endometriosis were treated with 600 mg of danazol daily for 24 weeks. The molar and fractional lecithin:cholesterol acyl transfer (LCAT) rates and the concentrations of cholesterol, phospholipids, and triglycerides were determined in plasma and in the very low-density lipoprotein, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and HDL2 and HDL3 fractions before, during, and after the medication. After 2 weeks the HDL, HDL2, and HDL3 cholesterol concentrations were reduced by 49%, 73%, and 29%, respectively, while the LDL level was increased by 14%. The molar and fractional LCAT rates decreased during treatment, and these reduced LCAT rates are consistent with a reduced fractional LDL removal. Within 8 weeks after cessation of medication, all parameters had returned to the pretreatment levels. |
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Authors:
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L Fåhraeus; U Larsson-Cohn; S Ljungberg; L Wallentin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fertility and sterility Volume: 42 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-07-20 Completed Date: 1984-07-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 52-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholesterol / blood Danazol / pharmacology*, therapeutic use Endometriosis / blood*, drug therapy Female Humans Lipoproteins / blood* Lipoproteins, HDL / blood Lipoproteins, LDL / blood Lipoproteins, VLDL / blood Pelvic Neoplasms / blood*, drug therapy Phospholipids / blood Pregnadienes / pharmacology* Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Phospholipids; 0/Pregnadienes; 0/Triglycerides; 17230-88-5/Danazol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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