| Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment. | |
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MedLine Citation:
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PMID: 9843009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We compared the activity and tolerance profile of a 0.05% retinaldehyde cream with a 0.05% retinoic acid cream and the retinaldehyde vehicle in patients with photodamaged skin of the face. METHODS: A silicone replica of the left crow's feet area was taken at baseline and at weeks 18 and 44. Skin replicas were then analyzed by means of an optical profilometry technique. Standard wrinkle and roughness features were then calculated and statistically analyzed. The tolerance profile of the test products was also clinically evaluated during the entire study. RESULTS: A total of 125 patients (40 in the retinoic acid group, 40 in the retinaldehyde group, and 45 in the vehicle group) were studied. At week 18, a significant reduction of the wrinkle and roughness features was observed with both retinaldehyde and retinoic acid. At week 44, a less pronounced reduction was demonstrated in both active groups. No statistically significant changes were observed with the retinaldehyde vehicle at any assessment point. A total of 135 patients constituted the safety population. Retinaldehyde was well tolerated during the entire study. In contrast, retinoic acid caused more local irritation, and affected compliance of the patients. CONCLUSION: Retinaldehyde was efficacious and well tolerated in patients with photodamage. |
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Authors:
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P Creidi; M P Vienne; S Ochonisky; C Lauze; V Turlier; J M Lagarde; P Dupuy |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 39 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1998-12-17 Completed Date: 1998-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 960-5 Citation Subset: IM |
Affiliation:
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Department of Functional Dermatology, University Hospital, Besançon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Keratolytic Agents / therapeutic use* Male Middle Aged Ointments Reference Values Retinaldehyde / therapeutic use* Skin Aging / drug effects* Tretinoin / therapeutic use* Vehicles / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Keratolytic Agents; 0/Ointments; 0/Vehicles; 116-31-4/Retinaldehyde; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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