| Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium. | |
| | |
MedLine Citation:
|
PMID: 20813265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The evolution of the highest-order human brain center, the "pallium" or "cortex," remains enigmatic. To elucidate its origins, we set out to identify related brain parts in phylogenetically distant animals, to then unravel common aspects in cellular composition and molecular architecture. Here, we compare vertebrate pallium development to that of the mushroom bodies, sensory-associative brain centers, in an annelid. Using a newly developed protocol for cellular profiling by image registration (PrImR), we obtain a high-resolution gene expression map for the developing annelid brain. Comparison to the vertebrate pallium reveals that the annelid mushroom bodies develop from similar molecular coordinates within a conserved overall molecular brain topology and that their development involves conserved patterning mechanisms and produces conserved neuron types that existed already in the protostome-deuterostome ancestors. These data indicate deep homology of pallium and mushroom bodies and date back the origin of higher brain centers to prebilaterian times. |
| | |
Authors:
|
Raju Tomer; Alexandru S Denes; Kristin Tessmar-Raible; Detlev Arendt |
Related Documents
:
|
15922575 - A bmp-mediated transcriptional cascade involving cash1 and tlx-3 specifies first-order ... 12469125 - Zinc finger protein too few controls the development of monoaminergic neurons. 19609935 - Long-term, stable differentiation of human embryonic stem cell-derived neural precursor... 23056565 - Dysfunctional behavioral modulation of corticostriatal communication in the r6/2 mouse ... 733255 - Clinical applications of the auditory brain stem response. 15533625 - The meaning of mammalian adult neurogenesis and the function of newly added neurons: th... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cell Volume: 142 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-03 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
|
Languages: eng Pagination: 800-9 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Developmental Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg, Germany. tomer@embl.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Patterning Cerebral Cortex / physiology* Evolution* Humans Mushroom Bodies / physiology* Polychaeta / anatomy & histology, embryology, genetics, physiology* Vertebrates / anatomy & histology, genetics*, physiology |
| Comments/Corrections | |
Comment In:
|
Cell. 2010 Sep 3;142(5):679-81
[PMID:
20813256
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.
Next Document: The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteo...