| Profiling of adhesive properties of the ALS protein family, a virulent attribute of Candida albicans. | |
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MedLine Citation:
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PMID: 22321066 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Candida albicans is normally present in nearly all humans but can cause fatal diseases in immunocompromised patients. The ALS gene family of C. albicans has been suggested to be important for the biofilm formation on medical devices. Here, we cloned all ALS genes and determined the binding properties of their gene products by cell surface engineering of Saccharomyces cerevisiae. We found that most of the ALS homologues had the ability to bind polypropylene, borosilicate glass, and polyvinyl chloride, which are often used as materials in medical devices. However, ALS homologues were not able to bind polyurethane, polymethyl methacrylate, polytetrafluoroethylene, or titanium. These findings will aid in the development of biofilm-resistant medical devices. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
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Authors:
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Wataru Aoki; Nao Kitahara; Natsuko Miura; Hironobu Morisaka; Kouichi Kuroda; Mitsuyoshi Ueda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-9 |
Journal Detail:
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Title: FEMS immunology and medical microbiology Volume: - ISSN: 1574-695X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
Affiliation:
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Japan Society for the Promotion of Science, Sakyo-ku, Kyoto, 606-8502, Japan; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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