| Profiling Ubiquitin Linkage Specificities of Deubiquitinating Enzymes with Branched Ubiquitin Isopeptide Probes. | |
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MedLine Citation:
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PMID: 22689415 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Branching out: Novel branched ubiquitin isopeptide activity-based probes (UIPPs) were engineered to profile ubiquitin (Ub) linkage specificity of deubiquitinating enzymes (DUBs) in cell extracts. Using chemical proteomics, a preference towards K48-linked Ub was shown for USP5, USP7, UCH L-3, and UCH L-5, whereas USP19 and USP38 preferred K63-linked Ub. |
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Authors:
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Alexander Iphöfer; Anne Kummer; Manfred Nimtz; Antje Ritter; Tatjana Arnold; Ronald Frank; Joop van den Heuvel; Benedikt M Kessler; Lothar Jänsch; Raimo Franke |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-11 |
Journal Detail:
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Title: Chembiochem : a European journal of chemical biology Volume: - ISSN: 1439-7633 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Molecular Structural Biology, Cellular Proteomics, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig (Germany). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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