| Profiling of Hepatic Gene Expression of Mice Fed with Edible Japanese Mushrooms by DNA Microarray Analysis: Comparison among Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus. | |
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MedLine Citation:
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PMID: 21910414 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To compare and estimate the effects of dietary intake of three kinds of mushrooms (Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus), mice were fed a diet containing 10-14% of each mushroom for 4 weeks. Triacylglycerol in the liver and plasma decreased and plasma cholesterol increased in the P. ostreatus-fed group compared with those in the control group. Cholesterol in the liver was lower in the G. frondosa-fed group than in the control group, but no changes were found in the H. marmoreus-fed group. DNA microarray analysis of the liver revealed differences of gene expression patterns among mushrooms. Ctp1a and Fabp families were upregulated in the P. ostreatus-fed group, which were considered to promote lipid transport and β-oxidation. In the G. frondosa-fed group, not only the gene involved in signal transduction of innate immunity via TLR3 and interferon but also virus resistance genes, such as Mx1, Rsad2, and Oas1, were upregulated. |
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Authors:
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Mayumi Sato; Yoshihiko Tokuji; Shozo Yoneyama; Kyoko Fujii-Akiyama; Mikio Kinoshita; Masao Ohnishi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-12 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Forest Products Research Institute, Hokkaido Research Organization , Asahikawa, Hokkaido 071-0198, Japan. |
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