Document Detail


Profilin phosphorylation as a VEGFR effector in angiogenesis.
MedLine Citation:
PMID:  23033049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular endothelial growth factor (VEGF) signalling induces embryonic vascular development and angiogenesis in adult tissues. Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.
Authors:
Michael Simons; Martin A Schwartz
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Publication Detail:
Type:  News    
Journal Detail:
Title:  Nature cell biology     Volume:  14     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  2013-01-11     Revised Date:  2014-10-19    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  985-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Actins / physiology
Animals
Mice
Morphogenesis / physiology
Neovascularization, Physiologic*
Phosphorylation
Profilins / metabolism*
Receptors, Vascular Endothelial Growth Factor / physiology*
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
P01 HL107205/HL/NHLBI NIH HHS; R01 HL053793/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Actins; 0/Profilins; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor
Comments/Corrections

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