Document Detail

Profilin-1 overexpression restores adherens junctions in MDA-MB-231 breast cancer cells in R-cadherin-dependent manner.
MedLine Citation:
PMID:  19593789     Owner:  NLM     Status:  MEDLINE    
Profilin-1 (Pfn1), a ubiquitously expressed actin-binding protein, is downregulated in several different types of adenocarcinoma and elicits tumor-suppressive effect on breast cancer cell lines. MDA-MB-231 (MDA-231), a breast cancer cell line that displays all the characteristics of post-epithelial-to-mesenchymal transition and does not form cell-cell adhesion, can be reverted to an epithelioid phenotype by Pfn1 overexpression. This morphological transition is caused by restoration of adherens junctions (AJ) requiring Pfn1's interaction with actin. Pfn1 overexpression increases the expression level of R-cadherin (a type of cadherin that is endogenously expressed in the parental cell line) and restores AJ in MDA-231 cells in R-cadherin-dependent manner. These findings highlight important role of Pfn1 in the regulation of epithelial cell-cell adhesion.
Li Zou; Rachel Hazan; Partha Roy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cell motility and the cytoskeleton     Volume:  66     ISSN:  1097-0169     ISO Abbreviation:  Cell Motil. Cytoskeleton     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-02-05     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  8605339     Medline TA:  Cell Motil Cytoskeleton     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1048-56     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
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MeSH Terms
Actins / metabolism
Adherens Junctions / metabolism*,  ultrastructure
Breast Neoplasms / metabolism*,  ultrastructure*
Cadherins / genetics,  metabolism*
Cell Adhesion
Cell Communication
Cell Line, Tumor
Profilins / genetics,  metabolism*
Up-Regulation / genetics
Grant Support
R01 CA108607/CA/NCI NIH HHS; R01 CA108607-04/CA/NCI NIH HHS; R01-CA108607/CA/NCI NIH HHS
Reg. No./Substance:
0/Actins; 0/Cadherins; 0/Profilins; 0/R-cadherin

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