| Profiles of proinflammatory cytokines in sputum from different groups of severe asthmatic patients. | |
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MedLine Citation:
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PMID: 17042136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Severe asthma represents a heterogeneous group of patients whose characteristics of airway inflammation are poorly known. OBJECTIVE: To evaluate the sputum cytokine profiles of different phenotypes of severe asthma. METHODS: Severe asthmatic patients (n = 45) were divided into 3 groups: frequent exacerbations, persistent bronchoconstriction, and both features. Two other groups (9 patients with untreated mild asthma and 10 control subjects) were also studied. Selected sputum portions were assayed for differential cell count, supernatant interleukin 5 (IL-5), granulocyte-macrophage colony-stimulating factor, IL-8, and eosinophil cationic protein. RESULTS: There were no statistically significant differences among the 3 severe asthma groups in terms of sputum inflammatory cell percentages, IL-8 levels, and eosinophil cationic protein levels, although IL-8 levels tended to be higher in patients with persistent bronchoconstriction. Sputum concentrations of granulocyte-macrophage colony-stimulating factor and IL-5 were significantly higher in patients with frequent exacerbations compared with the other 2 groups. Levels of IL-5 and IL-8 were higher in severe asthmatic patients compared with mild asthmatic patients and controls, whereas sputum eosinophil percentages were intermediate between those of mild asthmatic patients and controls. CONCLUSIONS: Proeosinophilic cytokine levels are increased in severe asthmatic patients with frequent exacerbations but not in severe asthmatic patients with persistent bronchoconstriction, suggesting that different cytokine profiles could be associated with different phenotypes of severe asthma. |
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Authors:
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Federico L Dente; Stefano Carnevali; Maria Laura Bartoli; Silvana Cianchetti; Elena Bacci; Antonella Di Franco; Barbara Vagaggini; Pierluigi Paggiaro |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 97 ISSN: 1081-1206 ISO Abbreviation: Ann. Allergy Asthma Immunol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-10-17 Completed Date: 2006-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9503580 Medline TA: Ann Allergy Asthma Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 312-20 Citation Subset: IM |
Affiliation:
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Pulmonary Unit, Cardio-Thoracic Department, University of Pisa, Italy. FDente@excite.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Asthma / immunology* Biological Markers / analysis* Cytokines / immunology* Eosinophils / immunology Female Granulocyte-Macrophage Colony-Stimulating Factor / analysis, metabolism Humans Inflammation / immunology Interleukin-5 / analysis, metabolism Interleukin-8 / analysis, metabolism Male Middle Aged Neutrophils / immunology Sputum / chemistry, cytology, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cytokines; 0/Interleukin-5; 0/Interleukin-8; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
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