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Profiles of ortho-polychlorinated biphenyl congeners, dichlorodiphenyldichloroethylene, hexachlorobenzene, and Mirex among male Lake Ontario sportfish consumers: the New York State Angler cohort study.
MedLine Citation:
PMID:  15533334     Owner:  NLM     Status:  MEDLINE    
Great Lakes sportfish consumption is a recognized human exposure source to environmental organochlorine compounds. Using data collected as part of the New York State Angler Cohort Study, 203 males were considered with regard to history of Lake Ontario sportfish consumption and sera levels of 57 ortho-substituted polychlorinated biphenyl (PCB) congeners, dichlorodiphenyldichloroethylene, hexachlorobenzene, and Mirex. Consumption of six species of highly contaminated Lake Ontario sportfish during the years 1980 to 1990 was considered. Exposure was weighted by average annual frequency of consumption, whole-fish PCB estimates, and meal size to determine a continuous index of exposure. This index was dichotomized to compare "consumers" to "nonconsumers" in several procedures. Recovery and lipid-adjusted serum values for PCB congener IUPAC Nos. 138+163 (rsp=0.3), 183 (rsp=0.3), 187 (rsp=0.4), and 188 (rsp=0.3) and Mirex (rsp=0.4) were significantly correlated with the index of fish consumption (P<0.001). A logistic regression model, using forward stepwise selection procedures (alpha in/out=0.002/0.004), was employed to account for high intercorrelations among organochlorine predictor variables. Mirex was the sole statistically significant predictor variable of "consumer/nonconsumer." A one-unit increase in log Mirex was associated with a 92.0% increase in the odds of having reported sportfish consumption (OR=1.92, 95%CI=1.43, 2.58). Age, body mass index, cigarette smoking, water/wildfowl consumption, and year of sampling were considered covariates. The results of this study support the premise that long-term dietary consumption of Lake Ontario sportfish, even at comparatively low levels, contributes significantly to the body burden of organochlorine compounds in western New York anglers and sportsmen.
Michael S Bloom; John E Vena; Mya K Swanson; Kirsten B Moysich; James R Olson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Environmental research     Volume:  97     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2004-11-09     Completed Date:  2005-01-21     Revised Date:  2007-07-31    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-94     Citation Subset:  IM    
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, 270 Farber Hall, 3435 Main St. Buffalo, NY 14214-3000, USA.
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MeSH Terms
Cohort Studies
Dichlorodiphenyl Dichloroethylene / blood
Food Contamination*
Great Lakes Region
Hexachlorobenzene / blood
Hydrocarbons, Chlorinated / blood*
Mirex / blood
New York / epidemiology
Polychlorinated Biphenyls / blood
Reg. No./Substance:
0/Hydrocarbons, Chlorinated; 0/Polychlorinated Biphenyls; 118-74-1/Hexachlorobenzene; 2385-85-5/Mirex; 72-55-9/Dichlorodiphenyl Dichloroethylene

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