Document Detail


Profiles of inflammatory markers and lipoprotein subclasses in patients undergoing continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  20654604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) often have inflammation and dyslipidemia that accelerate to atherosclerosis. This study aimed to evaluate chronic inflammation and dyslipidemia in CAPD patients.
METHODS: We measured inflammatory markers and lipoprotein subclasses in 20 CAPD patients (12 men and 8 women, aged 59.5 ± 9.9 y) and 20 gender-matched controls. Lipoproteins were separated by high-performance liquid chromatography (HPLC) using an anion-exchange column.
RESULTS: High-sensitivity C-reactive protein and serum amyloid A protein (SAA) were higher among CAPD patients vs. controls (1.6 ± 2.2 vs. 0.8 ± 1.2 mg/l, p<0.05; 11.9 ± 12.8 vs. 4.5 ± 2.4 mg/l). HPLC analysis revealed that chylomicron, VLDL, and IDL cholesterol levels were higher among CAPD vs. controls. In contrast, HDL cholesterol was lower among CAPD patients vs. controls. In the subgroup analysis, SAA levels were significantly lower among patients receiving CAPD for >3 y than among controls. However, IDL cholesterol was consistently higher among CAPD patients vs. controls.
CONCLUSIONS: CAPD patients have chronic inflammation and dyslipidemia. IDL cholesterol is the only lipoprotein subclass that is consistently elevated regardless of CAPD duration. More attention should be paid to dyslipidemia in the management of the CAPD patients.
Authors:
Mika Kon; Satoshi Hirayama; Yuki Horiuchi; Tsuyoshi Ueno; Mayumi Idei; Yuriko Fueki; Utako Seino; Shin Goto; Hiroki Maruyama; Noriaki Iino; Yoshifumi Fukushima; Hirotoshi Ohmura; Yuji Hirowatari; Takashi Miida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-21
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  411     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1723-7     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Clinical Laboratory Medicine, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers
Case-Control Studies
Cholesterol / blood
Dyslipidemias / diagnosis,  etiology
Female
Humans
Inflammation / diagnosis*,  etiology
Lipoproteins / blood*
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipoproteins; 0/lipoprotein cholesterol; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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