| Profiles of inflammatory markers and lipoprotein subclasses in patients undergoing continuous ambulatory peritoneal dialysis. | |
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MedLine Citation:
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PMID: 20654604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) often have inflammation and dyslipidemia that accelerate to atherosclerosis. This study aimed to evaluate chronic inflammation and dyslipidemia in CAPD patients. METHODS: We measured inflammatory markers and lipoprotein subclasses in 20 CAPD patients (12 men and 8 women, aged 59.5 ± 9.9 y) and 20 gender-matched controls. Lipoproteins were separated by high-performance liquid chromatography (HPLC) using an anion-exchange column. RESULTS: High-sensitivity C-reactive protein and serum amyloid A protein (SAA) were higher among CAPD patients vs. controls (1.6 ± 2.2 vs. 0.8 ± 1.2 mg/l, p<0.05; 11.9 ± 12.8 vs. 4.5 ± 2.4 mg/l). HPLC analysis revealed that chylomicron, VLDL, and IDL cholesterol levels were higher among CAPD vs. controls. In contrast, HDL cholesterol was lower among CAPD patients vs. controls. In the subgroup analysis, SAA levels were significantly lower among patients receiving CAPD for >3 y than among controls. However, IDL cholesterol was consistently higher among CAPD patients vs. controls. CONCLUSIONS: CAPD patients have chronic inflammation and dyslipidemia. IDL cholesterol is the only lipoprotein subclass that is consistently elevated regardless of CAPD duration. More attention should be paid to dyslipidemia in the management of the CAPD patients. |
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Authors:
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Mika Kon; Satoshi Hirayama; Yuki Horiuchi; Tsuyoshi Ueno; Mayumi Idei; Yuriko Fueki; Utako Seino; Shin Goto; Hiroki Maruyama; Noriaki Iino; Yoshifumi Fukushima; Hirotoshi Ohmura; Yuji Hirowatari; Takashi Miida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-21 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 411 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1723-7 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Clinical Laboratory Medicine, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers Case-Control Studies Cholesterol / blood Dyslipidemias / diagnosis, etiology Female Humans Inflammation / diagnosis*, etiology Lipoproteins / blood* Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipoproteins; 0/lipoprotein cholesterol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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