| Profiles of the fatty acids in the plasma membrane of human brain tumors. | |
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MedLine Citation:
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PMID: 9925279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies demonstrated that certain fatty acids have specific effects on tumor cells. n-3 series fatty acids (alpha-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid) may suppress the carcinogenesis, whereas n-6 series fatty acids (arachidonic acid, linoleic acid) may exert tumor promoting effects. In this study, 19 patients with various brain tumors and 12 control brain tissues were studied. n-3, n-6, n-9 unsaturated fatty acids and certain saturated fatty acids levels were measured in the plasma membrane of tumor or control brain tissues by capillary gas chromatography. We found that the level of docosahexaenoic acid from n-3 series fatty acids was significantly lower in gliomas and meningiomas than controls (p = 0.000). Total n-3 fatty acids level was also significantly lower in tumors than controls (p = 0.000). The levels of linoleic acid, arachidonic acid and dihomogamma linolenic acid from n-6 series were significantly higher in gliomas and meningiomas compared with controls (p = 0.000). Total n-6 fatty acids level was also significantly higher in tumors than controls (p = 0.000). Furthermore, in total n-9 fatty acids, total unsaturated fatty acids and total saturated fatty acids levels, there were no significant differences in gliomas and meningiomas compared with controls (p = 0.6840, p = 0.4388 and p = 0.4343, respectively). This findings suggest that n-6 fatty acids can act as a tumor-promoting agent in human brain tumors. |
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Authors:
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E Kökoğlu; Y Tüter; Z Yazici; K S Sandikci; H Sönmez; E Z Ulakoğlu; E Ozyurt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer biochemistry biophysics Volume: 16 ISSN: 0305-7232 ISO Abbreviation: Cancer Biochem. Biophys. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-03-22 Completed Date: 1999-03-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7506524 Medline TA: Cancer Biochem Biophys Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 301-12 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Chemistry* Brain Neoplasms / chemistry*, secondary, surgery Cell Membrane / chemistry Cerebellar Neoplasms / chemistry Chromatography, Gas / methods Fatty Acids, Nonesterified / analysis* Fatty Acids, Unsaturated / analysis* Humans Medulloblastoma / chemistry Membrane Lipids / analysis* Meningeal Neoplasms / chemistry Meningioma / chemistry Myristic Acid / analysis Neurilemmoma / chemistry Palmitic Acid / analysis Reference Values Stearic Acids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Membrane Lipids; 0/Stearic Acids; 544-63-8/Myristic Acid; 57-10-3/Palmitic Acid; 57-11-4/stearic acid |
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