Document Detail


Profiles of emetic action of cisplatin in the ferret: a potential model of acute and delayed emesis.
MedLine Citation:
PMID:  7813558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was investigated in the ferret over a 72 and 40 h period respectively. Cisplatin 10 mg/kg induced retching and vomiting which rapidly declined after the first 8 h. Cisplatin 5 mg/kg induced a less intense emetic response which declined after 16 h but reappeared at approximately 32 h to reveal a 'delayed' retching and vomiting response. The use of cisplatin 5 mg/kg may offer a regimen to model cytotoxic acute and delayed emesis.
Authors:
J A Rudd; C C Jordan; R J Naylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  262     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-08     Completed Date:  1995-02-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  R1-2     Citation Subset:  IM    
Affiliation:
School of Pharmacy, University of Bradford, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cisplatin / administration & dosage,  toxicity*
Disease Models, Animal*
Dose-Response Relationship, Drug
Ferrets*
Injections, Intraperitoneal
Male
Vomiting / chemically induced*
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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