| Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy. | |
| | |
MedLine Citation:
|
PMID: 21056499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: We determined the virological profile in Chinese chronic hepatitis B (CHB) subjects and its implications regarding current treatment guidelines. METHODS: A total of 1400 treatment-naïve CHB patients had their HBV DNA levels determined using the Cobas Taqman assay. Patient demographics, HBeAg status, and liver biochemistry were also recorded. RESULTS: The subjects were predominantly male (62%), had a median age of 45 years, and 301 (22%) were HBeAg-positive. In subjects aged ≤ 25, 26-35, 36-45, 46-55, and >55 years, there was a decreasing trend of HBV DNA levels of 9.9, 9.3, 8.2, 7.4, and 7.3 log copies/ml, respectively (p<0.001), in HBeAg-positive subjects, while the pattern was reversed with HBV DNA levels of 3.7, 4.4, 4.7, 4.9, and 5.2 log copies/ml, respectively, in HBeAg-negative subjects (p<0.001). In HBeAg-negative subjects, the proportion of patients with elevated ALT compared to those with normal ALT was significantly higher in older age groups (p<0.001). In our study population, by applying the AASLD, EASL, and APASL guidelines, 64%, 99%, and 64% would be eligible for antiviral therapy, respectively, in HBeAg-positive patients (with elevated ALT), and 38%, 72%, and 43%, respectively, in HBeAg-negative patients (with elevated ALT). Up to 54% of patients over the age of 40 years would be recommended for liver biopsy to determine further eligibility for treatment. CONCLUSIONS: For HBeAg-negative CHB, more patients had elevated ALT and a higher viral load with increasing age. Close monitoring is recommended in this group so that treatment may be considered. By applying the current treatment guidelines, a wide discrepancy can be observed in the proportion of patients eligible for treatment in the absence of histological data. |
| | |
Authors:
|
James Fung; Wai-Kay Seto; Ching-Lung Lai; John Yuen; Danny Ka-Ho Wong; Man-Fung Yuen |
Related Documents
:
|
6779949 - Factors contributing to mortality in paracetamol-induced hepatic failure. 2155699 - Inflammatory pseudotumor of the liver. clinicopathologic study and review of the litera... 15492609 - Prevalence and natural history of gastric antral vascular ectasia in patients undergoin... 1767249 - A survey of acute and chronic disease associated with yersinia enterocolitica infection... 1782729 - Heterogeneity of patients with late onset ornithine transcarbamylase deficiency. 10868639 - Dobutamine stress echocardiography in patients undergoing liver transplantation evaluat... 10730529 - Seizures after intracranial surgery in pediatric patients. 15198879 - Evaluation of von willebrand factor-cleaving protease activity in patients with thrombo... 7947269 - Increased expression of myeloid antigen markers in adult acute lymphoblastic leukaemia ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-19 |
Journal Detail:
|
Title: Journal of hepatology Volume: 54 ISSN: 1600-0641 ISO Abbreviation: J. Hepatol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-18 Completed Date: 2011-04-25 Revised Date: 2012-08-24 |
Medline Journal Info:
|
Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
|
Languages: eng Pagination: 195-200 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, Hong Kong. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Alanine Transaminase / blood China DNA, Viral / analysis* Female Hepatitis B e Antigens / analysis Hepatitis B virus / genetics, isolation & purification* Hepatitis B, Chronic / drug therapy, virology* Humans Male Middle Aged Viral Load |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral; 0/Hepatitis B e Antigens; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pre-operative liver biopsy in cirrhotic patients with early hepatocellular carcinoma represents a sa...
Next Document: The efficacy and safety of pegylated interferon plus ribavirin combination therapy in chronic hepati...