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Profiles of Great Lakes critical pollutants: a sentinel analysis of human blood and urine. The Great Lakes Consortium.
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MedLine Citation:
PMID:  9560354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the contaminants that should be studied further in the subsequent population-based study, a profile of Great Lakes (GL) sport fish contaminant residues were studied in human blood and urine specimens from 32 sport fish consumers from three Great Lakes: Lake Michigan (n = 10), Lake Huron (n = 11), and Lake Erie (n = 11). Serum was analyzed for 8 polychlorinated dioxin congeners, 10 polychlorinated furan congeners, 4 coplanar and 32 other polychlorinated biphenyl (PCB) congeners, and 11 persistent chlorinated pesticides. Whole blood was analyzed for mercury and lead. Urine samples were analyzed for 10 nonpersistent pesticides (or their metabolites) and 5 metals. One individual was excluded from statistical analysis because of an unusual exposure to selected analytes. Overall, the sample (n = 31) consumed, on average, 49 GL sport fish meals per year for a mean of 33 years. On average, the general population in the GL basin consume 6 meals of GL sport fish per year. The mean tissue levels of most persistent, bioaccumulative compounds also found in GL sport fish ranged from less than a twofold increase to that of PCB 126, which was eight times the selected background levels found in the general population. The overall mean total toxic equivalent for dioxins, furans, and coplanar PCBs were greater than selected background levels in the general population (dioxins, 1.8 times; furans, 2.4 times; and coplanar PCBs, 9.6 times). The nonpersistent pesticides and most metals were not identified in unusual concentrations. A contaminant pattern among lake subgroups was evident. Lake Erie sport fish consumers had consistently lower contaminant concentrations than consumers of sport fish from Lake Michigan and Huron. These interlake differences are consistent with contaminant patterns seen in sport fish tissue from the respective lakes; GL sport fish consumption was the most likely explanation for observed contaminant levels among this sample. Frequent consumers of sport fish proved to be effective sentinels for identifying sport fish contaminants of concern. In the larger study to follow, serum samples will be tested for PCBs (congener specific and coplanar), DDE, dioxin, and furans.
Authors:
H A Anderson; C Falk; L Hanrahan; J Olson; V W Burse; L Needham; D Paschal; D Patterson; R H Hill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental health perspectives     Volume:  106     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-02     Completed Date:  1998-09-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-89     Citation Subset:  IM    
Affiliation:
Wisconsin Division of Health, Bureau of Public Health, Madison 53703, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzofurans / blood
Diet
Fishes
Great Lakes Region
Humans
Metals / blood*,  urine*
Pesticides / blood*,  urine*
Polybrominated Biphenyls / blood
Polychlorinated Biphenyls / blood
Sentinel Surveillance*
Water Pollution*
Chemical
Reg. No./Substance:
0/Benzofurans; 0/Metals; 0/Pesticides; 0/Polybrominated Biphenyls; 0/Polychlorinated Biphenyls; 0/chlorinated dibenzofurans
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 5 Year: 1998
Volume: 106 Issue: 5
First Page: 279 Last Page: 289
ID: 1533095
PubMed Id: 9560354

Profiles of Great Lakes critical pollutants: a sentinel analysis of human blood and urine. The Great Lakes Consortium.
H A Anderson
C Falk
L Hanrahan
J Olson
V W Burse
L Needham
D Paschal
D Patterson, Jr
R H Hill, Jr
Wisconsin Division of Health, Bureau of Public Health, Madison 53703, USA.



Article Categories:
  • Research Article


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