Document Detail


Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis.
MedLine Citation:
PMID:  23421635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODS: Data were collected from cross-sectional, population-based sample of 244 centenarians (aged 98 to 108, 15.8% men, 20.5% African American, 38.0% community-dwelling) from 44 counties in northern Georgia participating in the Georgia Centenarian Study (2001-2008). Measures included the Mini-Mental State Examination (MMSE), Severe Impairment Battery (SIB), Wechsler Adult Intelligence Scale-III Similarities subtest (WAIS), Hand Tapping, Behavioral Dyscontrol Scale (BDS), Controlled Oral Word Association Test (COWAT), and Fuld Object Memory Evaluation (FOME). The Global Deterioration Rating Scale (GDRS) was used to independently evaluate criterion-related validity for distinguishing cognitively normal and impaired groups. Relevant covariates included directly assessed functional status for basic and instrumental activities of daily living (DAFS), race, gender, educational attainment, Geriatric Depression Scale Short Form (GDS), and vision and hearing problems.
RESULTS: Results suggest two distinct classes of cognitive performance in this centenarian sample. Approximately one third of the centenarians show a pattern of markedly lower cognitive performance on most measures. Group membership is independently well predicted (area under the curve [AUC] = .83) by GDRS scores (sensitivity 67.7%, specificity 82.4%). Membership in the lower cognitive performance group was more likely for individuals who were older, African Americans, had more depressive symptoms, lower plasma folate, carriers of the apolipoprotein E (APOE) ε4 allele, facility residents, and individuals who died in the 2 years following interview.
CONCLUSIONS: In a population expected to have high prevalence of dementia, latent subtypes can be distinguished via factor mixture analysis that provide normative values for cognitive functioning. The present study allows estimates for normative cognitive performance in this age group.
Authors:
Adam Davey; Ting Dai; John L Woodard; L Stephen Miller; Yasuyuki Gondo; Mary Ann Johnson; Dorothy B Hausman; Peter Martin; Robert C Green; Robert H Allen; Sally P Stabler; Leonard W Poon;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Experimental aging research     Volume:  39     ISSN:  1096-4657     ISO Abbreviation:  Exp Aging Res     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-06     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7603335     Medline TA:  Exp Aging Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over / psychology*
Apolipoproteins E / genetics
Cognition / classification*
Depression / epidemiology,  psychology
Factor Analysis, Statistical
Female
Folic Acid / blood
Georgia / epidemiology
Geriatric Assessment
Humans
Logistic Models
Male
Neuropsychological Tests
Psychiatric Status Rating Scales
Grant Support
ID/Acronym/Agency:
AG027841/AG/NIA NIH HHS; HG02213/HG/NHGRI NIH HHS; K24 AG027841/AG/NIA NIH HHS; P01 AG017553/AG/NIA NIH HHS; P01AG17553/AG/NIA NIH HHS; R01 CA158361/CA/NCI NIH HHS; R01 HG002213/HG/NHGRI NIH HHS; R01AG13180/AG/NIA NIH HHS; R01CA158361/CA/NCI NIH HHS; R21 CA158877/CA/NCI NIH HHS; R21CA158877/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 935E97BOY8/Folic Acid
Comments/Corrections

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