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Profile of urinary and fecal proanthocyanidin metabolites from common cinnamon (Cinnamomum zeylanicum L.) in rats.
MedLine Citation:
PMID:  22383303     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cinnamon (Cinnamomum zeylanicum L.) bark is widely used as a spice and in traditional medicine. Its oligomeric and polymeric proanthocyanidins are believed to be partly responsible for the beneficial properties of the plant. We describe here the metabolic fate of cinnamon proanthocyanidins in the urine and feces of rats fed a suspension of the whole bark. The metabolites include ten mono-, di-, and tri- conjugated (epi)catechin phase II metabolites and more than 20 small phenolic acids from intestinal microbial fermentation. Some of these are sulfated conjugates. Feces contain intact (epi)catechin and dimers. This suggests that free radical scavenging species are in contact with the intestinal walls for hours after ingestion of cinnamon. The phenolic metabolite profile of cinnamon bark in urine is consistent with a mixture of proanthocyanidins that are depolymerized into their constitutive (epi)catechin units as well as cleaved into smaller phenolic acids during their transit along the intestinal tract, with subsequent absorption and conjugation into bioavailable metabolites.
Authors:
María Luisa Mateos-Martín; Jara Pérez-Jiménez; Elisabet Fuguet; Josep Lluís Torres
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-1
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  -     ISSN:  1613-4133     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Barcelona, Spain.
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