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Profile of plasma amino Acid levels in rats exposed to acute hypoxic hypoxia.
MedLine Citation:
PMID:  23024481     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The effect of acute hypoxic hypoxia on the profile of plasma amino acids in rats was studied and compared to that resulting from acute liver injury induced by giving carbon tetrachloride. In hypoxic rats exposed to 45% air in N(2) for 5 h, the concentrations of branched chain amino acids, including valine, leucine and isoleucine, and aromatic amino acids such as phenylalanine and tyrosine were significantly increased as compared to those in normoxic rats. The ratio of branched-chain to aromatic amino acids (Fischer's ratio) was significantly decreased. The levels of arginine and citrulline, which are related to the urea cycle, were also depressed. Furthermore, plasma proline level was reduced in hypoxic rats. The activities of plasma marker enzymes for tissue damage remained unchanged during hypoxia, indicating that tissue injury was not induced by exposure to hypoxic conditions. We suggest that the characteristic profile of plasma amino acids and the Fischer ratio are valuable tools for understanding the pathology of acute hypoxia in the absence of systemic tissue damage.
Authors:
Haruhiro Muratsubaki; Akiko Yamaki
Publication Detail:
Type:  Journal Article     Date:  2011-04-07
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  26     ISSN:  0974-0422     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  416-9     Citation Subset:  -    
Affiliation:
Department of Clinical Chemistry, Faculty of Health Sciences, Kyorin University, Miyashita, Hachioji, Tokyo 192-8508 Japan.
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