Document Detail


Profile and outcome of neuroblastoma with convertional chemotherapy in children older than one year: a 15-years experience.
MedLine Citation:
PMID:  18310793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical profile and outcome of neuroblastoma in 103 children, older than one-year is presented. 74 had Stage IV, 27 Stage III and one patient each had Stage I or II disease. Treatment included chemotherapy followed by surgical resection/debulking. Radiotherapy was administered to those with residual tumor. Chemotherapy consisted of OPEC (vincristine, cyclophosphamide, cisplatin and etoposide). The caretakers of 54 (52.4%) children either did not opt for or defaulted therapy, whilst 3 patients died before chemotherapy could be initiated. Of the remaining 46 patients, the tumor progressed during therapy in 19 (41.3%). Relapse of disease was documented in 22 (47.8%) cases. Merely 4 (8.7%) children are disease free for a period of 16.5+/-6.7 months. Majority of children presented with advanced disease and the outcome was dismal with conventional non-myloablative chemotherapy.
Authors:
Deepak Bansal; R K Marwaha; Amita Trehan; K L N Rao; Vishal Gupta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  45     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Affiliation:
Pediatric Hematology/Oncology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Brain Neoplasms / drug therapy*,  pathology*,  surgery
Child
Child, Preschool
Female
Humans
Infant
Male
Neoplasm Recurrence, Local
Neoplasm Staging
Neuroblastoma / drug therapy*,  pathology*,  surgery

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