Document Detail


Profile of microorganisms and antimicrobial resistance at a tertiary care referral burn centre in Iran: emergence of Citrobacter freundii as a common microorganism.
MedLine Citation:
PMID:  18378087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infection and antimicrobial resistance are important issues in severe burn. The aims of this prospective study were to investigate the profile of microorganisms and resistance to antimicrobial agents in a tertiary referral burn centre; 113 people aged >10 years, with partial- or full-thickness burns, were included in the study. A total of 733 samples including 275 swabs, 164 tissue biopsies, 258 urine samples, 26 blood samples and 10 sputum samples were collected, from which 124 microorganisms were isolated. Pseudomonas aeruginosa and Citrobacter spp were the most prevalent isolates (57.3% and 35.5%, respectively); 95.5% of Citrobacter. isolates were Citrobacter freundii. Antibiogram results obtained from 15 antimicrobial agents demonstrated that imipenem was the most effective agent against P. aeruginosa, followed by ciprofloxacin and piperacillin/tazobactam (67.9%, 43% and 37.5% sensitive, respectively). At least 60% of all Citrobacter isolates were sensitive to various antimicrobial agents, the highest sensitivity being obtained by ceftazidime and cefepime (81.6% and 78.4%, respectively). Sensitivity of P. aeruginosa isolates to the agents of each antimicrobial class was significantly different (p<0.001). The incidence of C. freundii and the resistance of P. aeruginosa to anti-pseudomonas agents were exceptionally high.
Authors:
G Khorasani; E Salehifar; G Eslami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-02
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  34     ISSN:  1879-1409     ISO Abbreviation:  Burns     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-12     Completed Date:  2008-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  947-52     Citation Subset:  IM    
Affiliation:
Department of Surgery, Mazandaran University of Medical Sciences, Valliasre Blvard, Sari, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use
Burns / drug therapy,  microbiology*,  rehabilitation
Child
Ciprofloxacin / therapeutic use
Citrobacter freundii*
Cross-Sectional Studies
Drug Resistance, Multiple, Bacterial*
Enterobacteriaceae Infections / complications*,  drug therapy
Female
Humans
Imipenem / therapeutic use
Iran
Male
Microbial Sensitivity Tests
Middle Aged
Prospective Studies
Pseudomonas Infections / complications
Wound Infection / microbiology*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 74431-23-5/Imipenem; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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