Document Detail


Profile of HIV type 1 coreceptor tropism among Kenyan patients from 2009 to 2010.
MedLine Citation:
PMID:  23617327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A switch of HIV coreceptor usage from CCR5 to CXCR4 occurs in AIDS pathogenesis and may play a critical role in the use of entry inhibitors. To determine the potential usefulness of maraviroc and other CCR5 antagonists among drug-naive and experienced patients in Kenya, the env-C2-V3 gene was successfully sequenced in samples from 176 (98 men and 78 female) consenting subjects between January 2009 and December 2012. In silico CPSSM, webPSSM/, and (ds) Kernel tools were used in predicting coreceptor usage. On the basis of the env V3 loop sequences, 84.1% (148) were reported with R-5 tropism, 4.5% (5) were dual tropic, while 13.4% (23) were of X4 tropism. However, similar to previous studies conducted in Kenya on genetic diversity, HIV-1 subtype A1 (73.9%; 130/176) still remains the most dominant subtype. The high levels of R5 tropism among the studied Kenyan infected populations suggested the potential use of CCR5 antagonists as new therapeutic options in Kenya.
Authors:
Anthony Kebira Nyamache; Anne W T Muigai; Zipporah Ng'ang'a; Samoel A Khamadi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-05-21
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  29     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-19     Completed Date:  2013-11-12     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1105-9     Citation Subset:  IM; X    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/JN381630;  JN381631;  JN381632;  JN381633;  JN381634;  JN381635;  JN381636;  JN381637;  JN381638;  JN381639;  JN381640;  JN381641;  JN381642;  JN381643;  JN381644;  JN381645;  JN381646;  JN381647;  JN381648;  JN381649;  JN381650;  JN381651;  JN381652;  JN381653;  JN381654;  JN381655;  JN381656;  JN381657;  JN381658;  JN381659;  JN381660;  JN381661;  JN381662;  JN381663;  JN381664;  JN381665;  JN381666;  JN381667;  JN381668;  JN381669;  JN381670;  JN381671;  JN381672;  JN381673;  JN381674;  JN381675;  JN381676;  JN381677;  JN381678;  JN381679;  JN381680;  JN381681;  JN381682;  JN381683;  JN381684;  JN381685;  JN381686;  JN381687;  JN381688;  JN381689;  JN381690;  JN381691;  JN381692;  JN381693;  JN381694;  JN381695;  JN381696;  JN381697;  JN381698;  JN381699;  JN381700;  JN381701;  JN381702;  JN381703;  JN381704;  JN381705;  JN381706;  JN381707;  JN381708;  JN381709;  JN381710;  JN381711;  JN381712;  JN381713;  JN381714;  JN381715;  JN381716;  JN381717;  JN381718;  JN381719;  JN381720;  JN381721;  JN381722;  JN381723;  JN381724;  JN381725;  JN381726;  JN381727;  JN381728;  JN381729;  JN381730;  JN381731;  JN381732;  JN381733;  JN381734;  JN381735;  JN381736;  JN381737;  JN381738;  JN381739;  JN381740;  JN381741;  JN381742;  JN381743;  JN381744;  JN381745;  JN381746;  JN381747;  JN381748;  JN381749;  JN381750;  JN381751;  JN381752;  JN381753;  JN381754;  JN381755;  JN381756;  JN381757;  JN381758;  JN381759;  JN381760;  JN381761;  JN381762;  JN381763;  JN381764;  JN381765;  JN381766;  JN381767;  JN381768;  JN381769;  JN381770;  JN381771;  JN381772;  JN381773;  JN381774;  JN381775;  JN381776;  JN381777;  JN381778;  JN381779;  JN381780;  JN381781;  JN381782;  JN381783;  JN381784;  JN381785;  JN381786;  JN381787;  JN381788;  JN381789;  JN381790;  JN381791;  JN381792;  JN381793;  JN381794;  JN381795;  JN381796;  JN381797;  JN381798;  JN381799;  JN381800;  JN381801;  JN381802;  JN381803;  JN381804;  JN381805;  JN381806;  JN381807;  JN381808;  JN381809;  JN381810
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
Cyclohexanes / therapeutic use*
Female
HIV Envelope Protein gp120 / genetics*
HIV Infections / genetics*,  virology
HIV-1 / physiology*
Humans
Kenya
Male
Middle Aged
Molecular Sequence Data
Receptors, CCR5 / antagonists & inhibitors,  genetics*
Receptors, CXCR4 / genetics*
Sequence Analysis, DNA
Triazoles / therapeutic use*
Viral Tropism*
Young Adult
Chemical
Reg. No./Substance:
0/Cyclohexanes; 0/HIV Envelope Protein gp120; 0/Receptors, CCR5; 0/Receptors, CXCR4; 0/Triazoles; MD6P741W8A/maraviroc
Comments/Corrections

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