| Productivity of estrogens by human placental organ culture at different stages of gestation. | |
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MedLine Citation:
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PMID: 4092668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The productivity of estrogens from 6 to 39 weeks of pregnancy was assessed by using human placental organ culture. It was revealed that the placenta gains the capacity to generate a significant amount of estrogens at around 8 weeks of pregnancy. Therefore, it was suggested that the luteoplacental shift takes place between 6 and 8 weeks of gestation (or 4 to 6 weeks after fertilization). The productivity of estrogens showed a distinct difference before and after 10 weeks of pregnancy when the placental localization is established. The amount of estrone formed by the placenta before 10 weeks of pregnancy was 0.043 +/- 0.005 nanomoles/mg protein/hour (mean +/- s.e, n = 6), while it was 0.034 +/- 0.002 nanomoles/mg protein/hour from 10 weeks to term (mean +/- s.e, n = 18 ; not significantly different) during which no marked change was observed, however that of 17 beta-estradiol was 0.099 +/- 0.002 nanomoles/mg protein/hour (mean +/- s.e, n = 6) before 10 weeks of pregnancy and 0.072 +/- 0.002 nanomoles/mg protein/hour (mean +/- s.e, n = 18) from 10 weeks to term (significant difference with p less than 0.005). The 17 beta-estradiol/estrone ratio remained almost constant throughout pregnancy, which ranged from 2.00 to 3.00. |
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Authors:
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M Ogino |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Endocrinologia japonica Volume: 32 ISSN: 0013-7219 ISO Abbreviation: Endocrinol. Jpn. Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1986-04-21 Completed Date: 1986-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376546 Medline TA: Endocrinol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 607-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androstenedione
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metabolism Culture Techniques / methods Estradiol / biosynthesis* Estrone / biosynthesis* Female Humans Kinetics Organ Culture Techniques Placenta / cytology, metabolism* Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 53-16-7/Estrone; 63-05-8/Androstenedione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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