Document Detail

Production of tumour necrosis factor in Listeria monocytogenes-infected animals.
MedLine Citation:
PMID:  3997317     Owner:  NLM     Status:  MEDLINE    
Both mice and rabbits injected intravenously with viable Listeria monocytogenes and challenged with bacterial lipopolysaccharide release tumour necrosis factor (TNF) into the blood. Optimal conditions for production of murine TNF using Listeria were established. The cell-kill efficacy of Listeria-TNF and of Corynebacterium parvum-TNF are comparable. Also, the two sera have similar spectra of activity; a wide variety of murine and human tumour cell lines are vulnerable while others are not affected. Among the cell lines tested, Ehrlich ascites tumour (EAT) cell was found to be most susceptible to the cytotoxic effect of TNF. The advantages of using Listeria for producing TNF and using EAT cells in studying the mechanism of action of TNF are discussed.
D K Ha; S W Leung; K P Fung; Y M Choy; C Y Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of immunopharmacology     Volume:  7     ISSN:  0192-0561     ISO Abbreviation:  Int. J. Immunopharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-07-02     Completed Date:  1985-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7904799     Medline TA:  Int J Immunopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
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MeSH Terms
Cell Line
Glycoproteins / analysis*,  pharmacology
Growth Inhibitors / analysis*
Listeria Infections / metabolism*
Mice, Inbred ICR
Propionibacterium acnes
Tumor Necrosis Factor-alpha
Reg. No./Substance:
0/Glycoproteins; 0/Growth Inhibitors; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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