| Production and storage of nitric oxide in adaptation to hypoxia. | |
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MedLine Citation:
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PMID: 10534443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adaptation to hypobaric hypoxia is known to exert multiple protective effects related with nitric oxide (NO). However the effect of adaptation to hypoxia on NO metabolism has remained unclear in many respects. In the present work we studied the interrelation between NO production and storage in the process of adaptation to hypoxia. The NO production was determined by the total nitrite/nitrate concentration in rats plasma. The volume of NO store was evaluated in vitro by the magnitude of isolated aorta relaxation to diethyldithiocarbamate. It was shown that both the nitrite/nitrate level and the NO store increased as adaptation to hypoxia developed. Furthermore, the NO store volume significantly correlated with plasma nitrite/nitrate. Therefore, adaptation to hypoxia stimulates NO production and storage and these effects can potentially underlie NO-dependent beneficial effects of adaptation. |
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Authors:
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E B Manukhina; I Y Malyshev; B V Smirin; S Y Mashina; V A Saltykova; A F Vanin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Volume: 3 ISSN: 1089-8603 ISO Abbreviation: Nitric Oxide Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-12-08 Completed Date: 1999-12-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9709307 Medline TA: Nitric Oxide Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 393-401 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Academic Press. |
Affiliation:
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Institute of General Pathology and Pathophysiology, Baltijskaya 8, Moscow, 125315, Russia. manukh@orc.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Animals Anoxia / metabolism* Endothelium, Vascular / metabolism Male Nitrates / blood Nitric Oxide / biosynthesis*, metabolism Nitrites / blood Rats Rats, Wistar Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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