Document Detail

Production and secretion of thioredoxin from transformed human trophoblast cells.
MedLine Citation:
PMID:  9620837     Owner:  NLM     Status:  MEDLINE    
Thioredoxin is a redox active protein which has been implicated in reproductive processes. In this study we investigated the intracellular production and extracellular secretion of placental thioredoxin by human cytotrophoblast cell lines which were used as in-vitro model systems. Results clearly demonstrated that thioredoxin is not only synthesized by these cells but is also secreted and that while the intracellular thioredoxin is present only as a 12 kDa form, it would appear that the extracellular thioredoxin is present in two forms, a predominant 12 kDa form accompanied by a lower amount of a 10 kDa form. The observed localization and possible secretion of thioredoxin at the feto-maternal interface suggest important roles for this protein during pregnancy. Intracellular thioredoxin may be involved in the prevention of cellular damage due to oxidative stress whereas extracellular thioredoxin may act to integrate the actions of the cytokine network operating at the feto-maternal interface thereby assisting with implantation and the successful establishment of pregnancy.
G Di Trapani; A Perkins; F Clarke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular human reproduction     Volume:  4     ISSN:  1360-9947     ISO Abbreviation:  Mol. Hum. Reprod.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1999-01-04     Completed Date:  1999-01-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  IM    
School of Biomolecular and Biomedical Science, Griffith University, Queensland, Australia.
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MeSH Terms
Blotting, Western
Cell Line, Transformed
Cell-Free System / chemistry
Intracellular Fluid / chemistry
Thioredoxins / biosynthesis*,  isolation & purification,  secretion*
Trophoblasts / metabolism*,  secretion*
Tumor Cells, Cultured
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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