| Production of prostaglandins in homogenates of kidney medullae and cortices of spontaneously hypertensive rats fed menhaden oil. | |
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MedLine Citation:
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PMID: 6796798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Menhaden oil (MO), whose polyunsaturated fatty acids consist mainly of (n-3) fatty acids, was fed to spontaneously hypertensive rats to determine the effect of (n-3) fatty acid on the in vitro production of prostaglandins produced from arachidonic acid (20:4[n-6]). Capacity to form PGE2 and PGF2 alpha was impaired in homogenates of kidney medullae and cortices from rats fed the MO diet compared to rats fed the control diet. The lower amounts of diene prostaglandins produced corresponded to the decrease in the amount of 20:4 (n-6) in the tissue. Possibly changes produced in tissue lipids by dietary fatty acids affect prostaglandin production by reducing the availability of substrate in tissue lipids. |
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Authors:
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N W Schoene; A Ferretti; D Fiore |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lipids Volume: 16 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-02-25 Completed Date: 1982-02-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 866-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid Arachidonic Acids / metabolism Dietary Fats / pharmacology* Dinoprost Dinoprostone Fatty Acids / analysis Fish Oils* Hypertension / metabolism* Kidney Cortex / metabolism* Kidney Medulla / metabolism* Male Oils / pharmacology* Prostaglandins E / biosynthesis* Prostaglandins F / biosynthesis* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Dietary Fats; 0/Fatty Acids; 0/Fish Oils; 0/Oils; 0/Prostaglandins E; 0/Prostaglandins F; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 551-11-1/Dinoprost; 8002-50-4/Menhaden oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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