Document Detail


Production of podophyllotoxin in Linum linearifolium in vitro cultures.
MedLine Citation:
PMID:  20931076     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
For the first time, callus and suspension cultures of Linum linearifolium were initiated. Podophyllotoxin (PTOX), a strong antitumor precursor, was isolated from the calli and suspension, as a main lignan besides smaller amount of 6-methoxypodophyllotoxin (6MPTOX). L. linearifolium is now the third Linum species of section Syllinum, with PTOX as the main lignan. The amounts of lignans, especially PTOX, found in L. linearifolium cell cultures are quite high within the studied Linum species until now. The antiproliferative effects of extracts were tested in a panel of human tumor cell lines, using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide]-dye reduction assay. The lignan mixtures caused concentration-dependent inhibition of malignant cell proliferation and showed moderate cytotoxic activity. The results clearly demonstrate that the lignan mixture of L. linearifolium exerts inhibitory effects against malignant cells.
Authors:
I Ionkova; I Antonova; G Momekov; E Fuss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacognosy magazine     Volume:  6     ISSN:  0976-4062     ISO Abbreviation:  Pharmacogn Mag     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-10-08     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101300403     Medline TA:  Pharmacogn Mag     Country:  India    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  -    
Affiliation:
Faculty of Pharmacy, Department of Pharmacognosy, Medical University of Sofia, Dunav Str. 2, 1000 Sofia, Bulgaria.
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