Document Detail

Production of phycocyanin--a pigment with applications in biology, biotechnology, foods and medicine.
MedLine Citation:
PMID:  18563408     Owner:  NLM     Status:  MEDLINE    
C-phycocyanin (C-PC) is a blue pigment in cyanobacteria, rhodophytes and cryptophytes with fluorescent and antioxidative properties. C-PC is presently extracted from open pond cultures of the cyanobacterium Arthrospira platensis although these cultures are not very productive and open for contaminating organisms. C-PC is considered a healthy ingredient in cyanobacterial-based foods and health foods while its colouring, fluorescent or antioxidant properties are utilised only to a minor extent. However, recent research and developments in C-PC synthesis and functionality have expanded the potential applications of C-PC in biotechnology, diagnostics, foods and medicine: The productivity of C-PC has been increased in heterotrophic, high cell density cultures of the rhodophyte Galdieria sulphuraria that are grown under well-controlled and axenic conditions. C-PC purification protocols based on various chromatographic principles or novel two-phase aqueous extraction methods have expanded in numbers and improved in performance. The functionality of C-PC as a fluorescent dye has been improved by chemical stabilisation of C-PC complexes, while protein engineering has also introduced increased stability and novel biospecific binding sites into C-PC fusion proteins. Finally, our understanding of the physiological functions of C-PC in humans has been improved by a mechanistic hypothesis that links the chemical properties of the phycocyanobilin chromophores of C-PC to the natural antioxidant, bilirubin, and may explain the observed health benefits of C-PC intake. This review outlines how C-PC is produced and utilised and discusses the novel C-PC synthesis procedures and applications.
Niels T Eriksen
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-18
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  80     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-09     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-14     Citation Subset:  IM    
Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 49, Aalborg, Denmark.
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MeSH Terms
Algae, Red / genetics,  metabolism,  radiation effects
Cyanobacteria / genetics,  metabolism*,  radiation effects
Drug Industry
Food Microbiology*
Gene Expression Regulation
Industrial Microbiology*
Phycobiliproteins / metabolism
Phycocyanin / chemistry,  genetics,  isolation & purification,  metabolism*
Reg. No./Substance:
0/Phycobiliproteins; 11016-15-2/Phycocyanin

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