| Production of pharmacologic monodisperse aerosols. | |
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MedLine Citation:
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PMID: 6833036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monodisperse aerosols containing a range of chemical material, including pharmacologically active substances, were produced by using a modified Sinclair-LaMer condensation generator. Instead of the usual hot-wire technique, an ultrasonic nebulizer was used to suspend nuclei in the gas phase as an aqueous polydisperse aerosol. This technique allowed the generation of monodisperse oil (sebacate) aerosols containing nuclei of sodium chloride, histamine, methacholine, antigen, iron oxide, methylene blue, uranine, radioactive technetium pertechnetate, and technetium-labeled human serum albumin. Quantitative agonist activity was demonstrated for each active nucleus. Particle sizes ranged from 0.65 to 3 microns, with a geometric standard deviation of 1.1-1.2. This system can produce a stable, monodisperse, biologically active radiolabeled aerosol for a period of several hours. |
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Authors:
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G C Smaldone; H Itoh; D L Swift; J Kaplan; R Florek; W Wells; H N Wagner |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 54 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 393-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols* Animals Coloring Agents / diagnostic use Dogs Humans Lung / physiology Physiology / instrumentation Radioisotopes / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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HL-0046103/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Coloring Agents; 0/Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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