Document Detail

The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores.
MedLine Citation:
PMID:  22490877     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: The uremic solutes p-cresol sulfate (PCS) and indoxyl sulfate (IS) are generated by colon bacteria acting on food components that escape absorption in the small bowel. The production of these potentially toxic compounds may thus be influenced by diet. This study examined whether production of PCS and IS is different in vegetarians and omnivores.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The production of PCS and IS was assessed by measuring their urinary excretion rates in participants with normal kidney function. Studies were carried out in 15 vegetarians and 11 individuals consuming an unrestricted diet. Participants recorded food intake over 4 days and collected urine over the final 2 days of each of two study periods, which were 1 month apart.
RESULTS: Average PCS excretion was 62% lower (95% confidence interval [95% CI], 15-83) and average IS excretion was 58% lower (95% CI, 39-71) in vegetarians than in participants consuming an unrestricted diet. Food records revealed that lower excretion of PCS and IS in vegetarians was associated with a 69% higher (95% CI, 20-139) fiber intake and a 25% lower (95% CI, 3-42) protein intake. PCS and IS excretion rates varied widely among individual participants and were not closely correlated with each other but tended to remain stable in individual participants over 1 month.
CONCLUSIONS: PCS and IS production rates are markedly lower in vegetarians than in individuals consuming an unrestricted diet.
Kajal P Patel; Frank J-G Luo; Natalie S Plummer; Thomas H Hostetter; Timothy W Meyer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-05
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  7     ISSN:  1555-905X     ISO Abbreviation:  Clin J Am Soc Nephrol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-08     Completed Date:  2012-10-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  982-8     Citation Subset:  IM    
Department of Medicine, Palo Alto VA Health Care System, Stanford University, Palo Alto, California, USA.
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MeSH Terms
Biological Markers / urine
Cresols / urine*
Diet Records
Diet, Vegetarian*
Indican / urine*
Kidney / metabolism,  physiology
Middle Aged
Sulfuric Acid Esters / urine*
Time Factors
Grant Support
Reg. No./Substance:
0/4-cresol sulfate; 0/Biological Markers; 0/Cresols; 0/Sulfuric Acid Esters; 487-94-5/Indican

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