| Production of nitric oxide during surgery involving cardiopulmonary bypass. | |
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MedLine Citation:
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PMID: 9468164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Surgery involving cardiopulmonary bypass induces an inflammatory response due to the contact of blood with the extracorporeal circuit. In some patients, this inflammatory response leads to multiple organ failure and death. Inflammatory states may increase the production of nitric oxide, either by increasing the activity of constitutive enzyme systems or by inducing of inflammation-specific systems. We hypothesized that surgery involving cardiopulmonary bypass would increase the production of nitric oxide in association with the inflammatory response. DESIGN: Prospective, single center, observational study. SETTING: University-affiliated, tertiary referral cardiothoracic center. PATIENTS: Eleven adult patients undergoing routine myocardial revascularization. INTERVENTIONS: Surgery for myocardial revascularization. MEASUREMENTS AND MAIN RESULTS: Observations were made after induction of anesthesia, before bypass, after completion of the bypass, and on return to the recovery area. Parameters measured included hemodynamics, exhaled nitric oxide concentrations, plasma nitrate/nitrite concentration, plasma and bronchoalveolar lavage myeloperoxidase concentrations, and protein carbonyl conversion. All patients survived surgery. Oxygenation index fell significantly after bypass. Plasma myeloperoxidase increased significantly during the study period. Plasma carbonyl conversion also increased, although not significantly. Plasma nitrate/nitrite and airway nitric oxide concentrations did not change through the course of the study. CONCLUSION: Surgery involving cardiopulmonary bypass induced a demonstrable inflammatory response, but this response was not associated with increased nitric oxide production. |
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Authors:
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S J Brett; G J Quinlan; J Mitchell; J R Pepper; T W Evans |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Critical care medicine Volume: 26 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-02-26 Completed Date: 1998-02-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 272-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Critical Care, National Heart & Lung Institute, Royal Brompton Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Breath Tests / methods Bronchoalveolar Lavage Fluid / chemistry Cardiopulmonary Bypass* / methods Hemodynamics Humans Intraoperative Period Male Middle Aged Neutrophil Activation Nitric Oxide / analysis, biosynthesis* Postoperative Complications / metabolism, physiopathology Prospective Studies |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
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Crit Care Med. 1998 Feb;26(2):208-9
[PMID:
9468151
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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