| Production of new-to-nature sophorolipids by cultivating the yeast Candida bombicola on unconventional hydrophobic substrates. | |
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MedLine Citation:
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PMID: 21404247 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The naturally occurring sophorolipids synthesized by Candida bombicola possess-despite their overall heterogeneity-little variation in the length of the lipid tail. The range is limited to C16-C18 fatty acids and is governed by the specificity of a cytochrome P450 monooxygenase. However, incorporation of fatty acids differing from the conventional C16-C18 range could broaden up the application potential of sophorolipids. The incorporation of medium-chain fatty acids should render the molecules more hydrophilic and consequently improve their water solubility. Two strategies to circumvent this C16-C18 preference are described in this paper. The first one skips the controlling action of the cytochrome P450 enzyme by supplying the yeast with already hydroxylated substrates, while the other method is based on the deception of the enzyme by presenting it substrates structurally resembling stearic acid. This later strategy can be applied to create very specific tailor-made sophorolipids when combined with post-fermentive modification. Biotechnol. Bioeng. 2011; 108:734-741. © 2010 Wiley Periodicals, Inc. |
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Authors:
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Inge Van Bogaert; Steve Fleurackers; Simon Van Kerrebroeck; Dirk Develter; Wim Soetaert |
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Publication Detail:
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Type: Journal Article Date: 2010-11-26 |
Journal Detail:
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Title: Biotechnology and bioengineering Volume: 108 ISSN: 1097-0290 ISO Abbreviation: Biotechnol. Bioeng. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502021 Medline TA: Biotechnol Bioeng Country: United States |
Other Details:
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Languages: eng Pagination: 734-41 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley Periodicals, Inc. |
Affiliation:
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Laboratory of Industrial Biotechnology and Biocatalysis, Department of Biochemical and Microbial Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium; telephone: 32-9-264-60-34; fax: 32-9-264-62-31. inge.vanbogaert@ugent.be. |
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