| Production of lymphoid tumors in hamsters by direct implantation of normal human peripheral and umbilical cord leukocytes. | |
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MedLine Citation:
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PMID: 181336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral leukocytes from Epstein-Barr virus (EBV)-seropositive or seronegative normal adults, or human umbilical cord leukocytes infected or not infected with EBV, were directly transplanted into 50 newborn hamsters treated with anti-lymphocyte serum. Lymphoid tumors were produced after a latent period of 10-25 days in 39 animals: 8 of 14 recipients of seropositive donor leukocytes, 2 of 2 recipients of seronegative donor leukocytes, 13 of 15 recipients of EBV-infected cord leukocytes, and 16 of 19 recipients of non-infected cord leukocytes. EBV-determined nuclear antigen-positive human lymphoblastoid cell lines were established in vitro from tumors produced with seropositive donor leukocytes or EBV-infected cord leukocytes but not from tumors produced with seronegative donor leukocytes or non-infected cord leukocytes. The results indicate that EBV is not a prerequisite for in vivo production of tumors but necessary for in vitro establishment of lymphoblastoid cell lines from such tumors. |
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Authors:
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I Miyoshi; I Kubonishi; H Uchida; S Hiraki; Y Matsuda; T Tanaka; H Masuji; K Hiraki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 18 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 1976 Jul |
Date Detail:
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Created Date: 1976-10-01 Completed Date: 1976-10-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: DENMARK |
Other Details:
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Languages: eng Pagination: 67-75 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Antilymphocyte Serum / pharmacology Cell Line Chromosomes Cricetinae Culture Techniques Fetal Blood Fluorescent Antibody Technique Herpesvirus 4, Human Humans Infant, Newborn Leukemia, Experimental / immunology, pathology Leukemia, Lymphoid / immunology*, pathology Leukocyte Transfusion* Leukocytes / ultrastructure Lymphoma / immunology*, pathology Neoplasm Transplantation Neoplasms, Experimental / immunology, pathology Transplantation, Heterologous |
| Chemical | |
Reg. No./Substance:
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0/Antilymphocyte Serum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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