Document Detail

Production of leukotrienes and prostaglandins by human ascites cells.
MedLine Citation:
PMID:  3007158     Owner:  NLM     Status:  MEDLINE    
Ascites was collected from six patients with liver cirrhosis and the cells isolated. These cells, mainly macrophages, were labelled with 14C-arachidonic acid and stimulated with the calcium ionophore A23187. The metabolites formed were separated by HPLC. The main substances formed by the ascites cells were leukotriene B4, 5-hydroxy-6,8,11,14 eicosatetraenoic acid and leukotriene C4. Smaller amounts of thromboxane B2, 12-hydroxy-5,8,10 heptodecatrienoic acid and 6-keto-prostaglandin F1 alpha were isolated. Human peritoneal macrophages are therefore capable of producing leukotrienes and prostaglandins. Production of these substances might play a role in some of the complications of patients with liver cirrhosis and ascites.
R J Ouwendijk; F J Zijlstra; J H Wilson; J E Vincent; I L Bonta
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  15     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-04-29     Completed Date:  1986-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Ascites / metabolism*
Fatty Acids, Unsaturated / biosynthesis*
Hydroxyeicosatetraenoic Acids / biosynthesis
Leukotriene B4 / biosynthesis
Liver Cirrhosis / metabolism
Prostaglandins / biosynthesis*
SRS-A / biosynthesis
Thromboxane B2 / biosynthesis
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids, Unsaturated; 0/Hydroxyeicosatetraenoic Acids; 0/Prostaglandins; 0/SRS-A; 506-32-1/Arachidonic Acid; 54397-85-2/Thromboxane B2; 71160-24-2/Leukotriene B4; 72255-35-7/5-hydroxy-6,8,11,14-eicosatetraenoic acid

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