| Production of leukotrienes and prostaglandins by human ascites cells. | |
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MedLine Citation:
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PMID: 3007158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ascites was collected from six patients with liver cirrhosis and the cells isolated. These cells, mainly macrophages, were labelled with 14C-arachidonic acid and stimulated with the calcium ionophore A23187. The metabolites formed were separated by HPLC. The main substances formed by the ascites cells were leukotriene B4, 5-hydroxy-6,8,11,14 eicosatetraenoic acid and leukotriene C4. Smaller amounts of thromboxane B2, 12-hydroxy-5,8,10 heptodecatrienoic acid and 6-keto-prostaglandin F1 alpha were isolated. Human peritoneal macrophages are therefore capable of producing leukotrienes and prostaglandins. Production of these substances might play a role in some of the complications of patients with liver cirrhosis and ascites. |
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Authors:
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R J Ouwendijk; F J Zijlstra; J H Wilson; J E Vincent; I L Bonta |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 15 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-04-29 Completed Date: 1986-04-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 327-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arachidonic Acid Arachidonic Acids / metabolism Ascites / metabolism* Fatty Acids, Unsaturated / biosynthesis* Humans Hydroxyeicosatetraenoic Acids / biosynthesis Leukotriene B4 / biosynthesis Liver Cirrhosis / metabolism Prostaglandins / biosynthesis* SRS-A / biosynthesis Thromboxane B2 / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Fatty Acids, Unsaturated; 0/Hydroxyeicosatetraenoic Acids; 0/Prostaglandins; 0/SRS-A; 506-32-1/Arachidonic Acid; 54397-85-2/Thromboxane B2; 71160-24-2/Leukotriene B4; 72255-35-7/5-hydroxy-6,8,11,14-eicosatetraenoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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