Document Detail

Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri.
MedLine Citation:
PMID:  3245697     Owner:  NLM     Status:  MEDLINE    
Lactobacillus reuteri is a prominent member of the Lactobacillus population in the gastrointestinal ecosystem of humans, poultry, swine, and other animals. Reuterin is a newly discovered, broad-spectrum antimicrobial substance produced by this species during fermentation of glycerol. In this report, we describe procedures for (i) producing reuterin in sufficient amounts to isolate from a fermentation mixture and (ii) isolating this substance by high-performance liquid chromatography. By using uniformly labeled [14C]glycerol, reuterin was identified as a product of glycerol fermentation associated with the production of beta-hydroxypropionic acid and trimethylene glycol.
T L Talarico; I A Casas; T C Chung; W J Dobrogosz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  32     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2010-09-09    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1854-8     Citation Subset:  IM    
Department of Microbiology, North Carolina State University, Raleigh 27695.
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MeSH Terms
Anti-Bacterial Agents / biosynthesis*,  isolation & purification
Antifungal Agents / isolation & purification*
Antiprotozoal Agents / isolation & purification*
Glyceraldehyde / analogs & derivatives
Glycerol / metabolism
Growth Inhibitors / biosynthesis*,  isolation & purification
Lactobacillus / metabolism*
Reg. No./Substance:
0/Aldehydes; 0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Antiprotozoal Agents; 0/Growth Inhibitors; 2134-29-4/3-hydroxypropionaldehyde; 367-47-5/Glyceraldehyde; 56-81-5/Glycerol; 74-98-6/Propane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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