Document Detail

Production of interferon-gamma by tonsillar mononuclear cells in IgA nephropathy patients.
MedLine Citation:
PMID:  11039878     Owner:  NLM     Status:  MEDLINE    
Much evidence, both in vivo and in vitro, suggests that patients with IgA nephropathy (IgAN) have enhanced IgA production. We hypothesized that Haemophilus parainfluenzae (HP) in the tonsil plays an important role in the IgA production of IgAN patients. In this study, we focused on interferon-gamma (IFN-gamma) and IgA production by tonsillar mononuclear cells (TMC) in patients with IgAN. Tonsillectomies were performed in patients with IgAN and chronic tonsillitis (CT). The induction of IFN-gamma and IgA in vitro by TMC from IgAN patients was compared with that from CT patients. In addition, we investigated whether stimulation with the outer membranes of HP (OMHP) enhanced IFN-gamma and IgA induction by TMC from patients with IgAN. Spontaneous IFN-gamma production and spontaneous total IgA production by TMC were higher in IgAN patients than in those patients with CT (p < 0.05). IFN-gamma induction by OMHP stimulation was also higher in IgAN patients than in CT patients. The stimulation of OMHP enhanced HP-specific IgA in IgAN but had no influence on the production of IFN-gamma in patients with either IgAN or CT compared with spontaneous IFN-gamma production. IFN-gamma production was positively correlated with total IgA values in both IgAN and CT patients, but not with HP-specific IgA. These results suggest that increased IFN-gamma production in patients with IgAN is not associated with HP infection but may play a role in the pathogenesis of IgAN.
S Fujieda; S Suzuki; H Sunaga; H Yamamoto; M Seki; H Sugimoto; H Saito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  120     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-02-13     Completed Date:  2001-02-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  649-54     Citation Subset:  IM    
Department of Otorhinolaryngology , Fukui Medical University, Japan.
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MeSH Terms
Adenoids / immunology*,  metabolism
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Glomerulonephritis, IGA / immunology,  metabolism*
Haemophilus Infections / immunology
Immunoglobulin A / immunology*
Interferon-gamma / immunology,  metabolism*
Leukocytes, Mononuclear / metabolism*
Middle Aged
Tonsillitis / immunology,  metabolism,  microbiology
Reg. No./Substance:
0/Immunoglobulin A; 82115-62-6/Interferon-gamma

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