| Production of glucuronic acid-based polysaccharides by microbial fermentation for biomedical applications. | |
| | |
MedLine Citation:
|
PMID: 22125298 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
This review provides an overview of the properties, different biosynthetic machineries, and biotechnological production processes of four microbially derived glucuronic acid-based polysaccharides that are of interest for diverse biomedical purposes. In particular, the utilization of hyaluronic acid and heparin sulfate in high-value medical applications is already well established, whereas chondroitin sulfate and alginate show high potential within this ever-growing field. Furthermore, new strategies exploiting genetically engineered microorganisms generated through improving naturally existing pathways or de novo designed ones are described. These new developments result in increased fermentation titers, and thereby, pave the way towards feasible, or at least improved, process economy. Moreover, these strategies also allow for the future possibility of producing tailor-made biopolymers with specified characteristics, even novel molecules. |
| | |
Authors:
|
Donatella Cimini; Mario De Rosa; Chiara Schiraldi |
Related Documents
:
|
21893398 - Selective electrooxidation of uric acid in presence of ascorbic acid at a room temperat... 12453578 - Isolation and identification of an allelopathic substance from peel of citrus junos. 21867458 - Chemical and biological study of the seeds of eragrostis tef (zucc.) trotter. 22136518 - Broad substrate specificity of the amide synthase in s. hygroscopicus - new 20-membered... 12392088 - Studies on the antioxidant activity of lippia citriodora infusion: scavenging effect on... 17872998 - Differences in membrane acyl phospholipid composition between an endothermic mammal and... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-29 |
Journal Detail:
|
Title: Biotechnology journal Volume: - ISSN: 1860-7314 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101265833 Medline TA: Biotechnol J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Second University of Naples, Department of Experimental Medicine, Section of Biotechnology and Molecular Biology, Naples, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolic network modeling and simulation for drug targeting and discovery.
Next Document: Diagnostic accuracy of plasma glial fibrillary acidic protein for differentiating intracerebral hemo...