Document Detail

Production of fumaric acid using rice bran and subsequent conversion to succinic acid through a two-step process.
MedLine Citation:
PMID:  15054237     Owner:  NLM     Status:  MEDLINE    
The fungal production of fumaric acid using rice bran and subsequent bacterial conversion of succinic acid using fungal culture broth were investigated. Since the rice bran contains abundant proteins, amino acids, vitamins, and minerals, it is suitable material that fungi use as a nitrogen source. The effective concentration of rice bran to produce fumaric acid was 5 g/L. A large amount of rice bran caused excessive fungal growth rather than enhance fumaric acid production. In addition, we could produce fumaric acid without the addition of zinc and iron. Fungal culture broth containing approx 25 g/L of fumaric acid was directly employed for succinic acid conversion. The amount of glycerol and yeast extract required for succinic acid conversion was reduced to 70 and 30%, respectively, compared with the amounts cited in previous studies.
Se-Kwon Moon; Young-Jung Wee; Jong-Sun Yun; Hwa-Won Ryu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied biochemistry and biotechnology     Volume:  113-116     ISSN:  0273-2289     ISO Abbreviation:  Appl. Biochem. Biotechnol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-31     Completed Date:  2004-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8208561     Medline TA:  Appl Biochem Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  843-55     Citation Subset:  IM    
School of Biological Sciences and Technology, Institute of Bioindustrial Technology, Chonnam National University, Gwangju 500-757, Korea.
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MeSH Terms
Biochemistry / methods*
Biotechnology / methods*
Carbon / chemistry
Cell Division
Dose-Response Relationship, Drug
Enterococcus faecalis / metabolism
Fumarates / chemistry*,  metabolism*
Glycerol / chemistry
Oryza sativa / chemistry*
Rhizopus / metabolism
Succinic Acid / chemistry*,  metabolism
Time Factors
Reg. No./Substance:
0/Fumarates; 110-15-6/Succinic Acid; 110-17-8/fumaric acid; 56-81-5/Glycerol; 7440-44-0/Carbon

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