Document Detail

Production of a cytotoxin by Helicobacter pylori.
MedLine Citation:
PMID:  1925309     Owner:  NLM     Status:  MEDLINE    
Helicobacter pylori produces a cytotoxin that was initially detected as the ability of broth culture filtrates of this bacterium to induce intracellular vacuolation of cultured cells. Fifty-three percent of more than 200 isolates of H. pylori tested produce the cytotoxin, which appears to be unique to H. pylori. Results of characterization studies suggest that the cytotoxin is a high-molecular-weight protein. Detection of serum antibody to the cytotoxin by neutralization or immunoblotting indicates that this toxin is produced in vivo. The cytotoxin is more frequently associated with cases of peptic ulceration than with cases of gastritis; this finding suggests that the toxin contributes to the severity of disease associated with H. pylori infection.
R D Leunk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  13 Suppl 8     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1991 Jul-Aug
Date Detail:
Created Date:  1991-11-20     Completed Date:  1991-11-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S686-9     Citation Subset:  IM    
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
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MeSH Terms
Cytotoxins / biosynthesis*
Helicobacter Infections / microbiology*
Helicobacter pylori / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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