| Production of cytokines by mouse peritoneal cells treated with Tołpa Torf Preparation (TTP): dependence on age and strain of mice. | |
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MedLine Citation:
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PMID: 8239912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Production of two cytokines: Interferon beta (IFN-beta) and tumor necrosis factor alpha (TNF-alpha) by freshly isolated resident mouse peritoneal cells (RPC) treated with immunostimulating drug Tołpa* Torf Preparation (TTP) was investigated. Nontoxic concentrations of TTP (10 and 100 micrograms/ml) potentiated the cytokine production by RPC of BALB/c mice. The observed effects were dose-dependent. The optimal cytokine-inducing concentration of TTP was 100 micrograms/ml. The effect of TTP depended on the age of mice. The high potentiation (16-fold) of IFN-beta and TNF-alpha production by TTP was observed when 5 and 8 week-old mice were used. However, in RPC isolated from one year old mice, only two (fold) potentiation of IFN and TNF was observed. The activities of the same commercial preparations of TTP were compared in the RPC cultures isolated from mice of the three different strains: BALB/c, C3H/HeJ and NZB. The significant stimulation (16-32-fold) of TNF and IFN was observed in the cells isolated from BALB/c mice. In contrast, only slight stimulation of IFN and TNF (1-3-fold) was observed in cells of NZB mice. Peritoneal cells of C3H mice did not respond to stimulation with TTP. |
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Authors:
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Z Błach-Olszewska; E Zaczyńska; E Broniarek; A D Inglot |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archivum immunologiae et therapiae experimentalis Volume: 41 ISSN: 0004-069X ISO Abbreviation: Arch. Immunol. Ther. Exp. (Warsz.) Publication Date: 1993 |
Date Detail:
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Created Date: 1993-12-06 Completed Date: 1993-12-06 Revised Date: 2006-04-17 |
Medline Journal Info:
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Nlm Unique ID: 0114365 Medline TA: Arch Immunol Ther Exp (Warsz) Country: POLAND |
Other Details:
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Languages: eng Pagination: 81-5 Citation Subset: IM |
Affiliation:
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Laboratory of Virology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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pharmacology* Age Factors Amino Acids / pharmacology* Animals Carbohydrates / pharmacology* Cells, Cultured Drug Combinations Female Humic Substances / pharmacology* Interferon Inducers / pharmacology* Interferon-beta / biosynthesis* Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred NZB Peritoneal Cavity / cytology Soil / analysis* Species Specificity Tumor Necrosis Factor-alpha / biosynthesis* Uronic Acids / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Amino Acids; 0/Carbohydrates; 0/Drug Combinations; 0/Humic Substances; 0/Interferon Inducers; 0/Soil; 0/Tolpa; 0/Tumor Necrosis Factor-alpha; 0/Uronic Acids; 77238-31-4/Interferon-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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