Document Detail

Production of cyclic nucleotides from normal human brain.
MedLine Citation:
PMID:  6318403     Owner:  NLM     Status:  MEDLINE    
Concentrations of cyclic AMP and cyclic GMP in arterial and internal jugular venous (IJV) blood were determined at the resting wakeful state in thirty surgical patients without neurological deficits. The levels of cyclic AMP in artery and IJV were 32.1 +/- 3.0 and 40.0 +/- 4.1 pmol/ml (means +/- standard errors), respectively, while those of cyclic GMP in artery and IJV were 12.2 +/- 2.7 and 14.4 +/- 3.0 pmol/ml, respectively. Concentrations of both cyclic nucleotides in IJV were significantly higher (P less than 0.001) than those in artery. IJV-arterial differences for cAMP and cGMP were 7.9 +/- 1.7 and 2.1 +/- 0.5 pmol/ml, respectively. The results indicate that both cyclic nucleotides are constantly produced and released from the normal human brain.
E Naito; K Shimoji; H Endoh; T Ichikawa; M Hashiba
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  14     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1983 May-Jun
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  380-2     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism*
Cyclic AMP / blood
Cyclic GMP / blood
Jugular Veins
Middle Aged
Nucleotides, Cyclic / blood*
Surgical Procedures, Operative
Wakefulness / physiology
Reg. No./Substance:
0/Nucleotides, Cyclic; 60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP

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